Cinnamic acids and derivatives
eMolecules 32862-97-8 | 3-Bromocinnamic acid | Oakwood Chemicals227.057 | C9H7BrO2 | 98.000 | OC(=O)\C=C\c1cccc(Br)c1 | 1g | 480099101
3-Bromocinnamic acid | Oakwood Chemicals | 32862-97-8227.057 | C9H7BrO2 | 98.000 | OC(=O)\C=C\c1cccc(Br)c1 | 1g | 480099101
Apexbio Technology LLC Tyrphostin AG 1296 146535-11-7 10mM (in 1mL DMSO)
Tyrphostin AG 1296 (CAS 146535-11-7) is a selective inhibitor of platelet-derived growth factor receptor (PDGFR) kinase via ATP-competitive binding Its inhibitory activity (IC50 0 3 0 5 M) results from inducing conformational changes in the ATP-binding domain of PDGFR blocking receptor autophosphorylation induced by ligand binding In vitro studies demonstrate inhibition of PDGF-stimulated mitogenesis (IC50 1 5 M) and cell proliferation (IC50 3 2 M) using Swiss 3T3 cells without significant effects on EGF receptor signaling at concentrations up to 100 M Tyrphostin AG 1296 serves as a research tool for investigating PDGFR-mediated signaling pathways
Apexbio Technology LLC Tyrphostin AG 1296 146535-11-7 100mg
Tyrphostin AG 1296 (CAS 146535-11-7) is a selective inhibitor of platelet-derived growth factor receptor (PDGFR) kinase via ATP-competitive binding Its inhibitory activity (IC50 0 3 0 5 M) results from inducing conformational changes in the ATP-binding domain of PDGFR blocking receptor autophosphorylation induced by ligand binding In vitro studies demonstrate inhibition of PDGF-stimulated mitogenesis (IC50 1 5 M) and cell proliferation (IC50 3 2 M) using Swiss 3T3 cells without significant effects on EGF receptor signaling at concentrations up to 100 M Tyrphostin AG 1296 serves as a research tool for investigating PDGFR-mediated signaling pathways
eMolecules 6099-03-2 | 2-Methoxycinnamic acid | Ambeed178.187 | C10H10O3 | 98.000 | COc1ccccc1C=CC(O)=O | 5g | 490558558
2-Methoxycinnamic acid | Ambeed | 6099-03-2178.187 | C10H10O3 | 98.000 | COc1ccccc1C=CC(O)=O | 5g | 490558558
eMolecules 66417-46-7 | 3-Hydroxycinnamic acid methyl ester | Combi-Blocks | MFCD09259949 | 178.187 | C10H10O3 | 98.000 | COC(=O)\C=C\c1cccc(O)c1 | 1g | 232339016
3-Hydroxycinnamic acid methyl ester | Combi-Blocks | 66417-46-7 | MFCD09259949 | 178.187 | C10H10O3 | 98.000 | COC(=O)\C=C\c1cccc(O)c1 | 1g | 232339016
Medchemexpress LLC cis-Ferulic acid 4-O-β-D-glucopyranoside | 94942-20-8 | 356.32 | 5 MG
cis-Ferulic acid 4-O-β-D-glucopyranoside (compound 7) is a phenolic glycosid, which can be isolated from Nitraria sibirica. This compound exhibits antioxidant activity and a potent inhibitory effect on Phosphatase PTP1B.
- Exhibits antioxidant activity.
- Potent inhibitory effect on Phosphatase PTP1B.
Medchemexpress LLC 4-Methoxycinnamic acid | 830-09-1 | 178.19 | 50 G
4-Methoxycinnamic acid is a natural phenylpropanoid found in A. preissii. This unique compound plays a role in phenylphenalenone biosynthesis. It is intended for research use only.
- Detected as a natural phenylpropanoid
- Involved in phenylphenalenone biosynthesis
- Suitable for research applications
Medchemexpress LLC 3,4-Dimethoxycinnamic acid | 2316-26-9 | 208.21 | 1 G
3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata Hassk. It exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway.
- Attenuates the ethanol-induced apoptosis of ethanol-exposed L-02 cells
- Inhibits the expression levels of Nox4 and p22phox in L-02 cells
- Attenuates ethanol-induced MAPK phosphorylation in L-02 cells
- Decreases the expression levels of superoxide dismutase, catalase and phospholipid hydroperoxide gluthione peroxidase
- Downregulates the levels of Bax/Bcl-2 and the cleaved forms of caspase-3 in a dose- and time-dependent manner
![Research Products International Corp Trans-Cinnamic Acid [B-Phenylacrylic acid], 25 Grams](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00006095-C34400-25.0.JPG-250.jpg)
Research Products International Corp Trans-Cinnamic Acid [B-Phenylacrylic acid], 25 Grams
Auxin like growth regulator.
Apexbio Technology LLC Curcumin(Synonyms: Diferuloylmethane, Turmeric yellow, Natural yellow 3, CI 75300), 10mM (in 1mL DMSO), CAS: 458-37-7.
Curcumin (CAS 458-37-7) is a natural small molecule known to inhibit tyrosinase activity with an IC50 of 47 M It modulates multiple signaling pathways involved in tumorigenesis and inflammation influencing transcription factors growth factors cytokines receptors and enzymes Clinical trials at Phase I reported no observed toxicity at doses up to 12 g/day however oral bioavailability is limited ( 1% in Phase I/II studies) Additionally curcumin demonstrates potential for Alzheimer s research as evidenced by reducing beta-amyloid (A 40 A 42) production via downregulating presenilin-1 and GSK-3 in SH-SY5Y neuroblastoma cells
Cayman Chemical m-CoumarIc AcId 10g
An active metabolite of polyphenols; inhibits cumene hydroperoxide-induced oxidation of DNA (IC50 = 54.7 µM); induces neurite outgrowth of fetal rat hippocampal neurons at 10 µM; induces apoptosis and cell cycle arrest at the G0/G1 phase in HeLa cells at 5 and 10 mM, respectively; increases locomotor activity in mice at 3 mmol/kg
Apexbio Technology LLC Tyrphostin 9 10537-47-0 25mg
Tyrphostin 9 is a selective inhibitor targeting platelet-derived growth factor receptor (PDGFR) and epidermal growth factor receptor (EGFR) It inhibits PDGFR autophosphorylation with an IC50 of approximately 2 5 M and EGFR kinase activity (IC50 around 460 M) Additionally Tyrphostin 9 inhibits platelet-derived growth factor (PDGF)-stimulated smooth muscle cell proliferation (IC50 approximately 40 nM) as well as phosphorylation of phospholipase C gamma (PLC IC50 2 5 M) and induction of PDGF-dependent c-fos expression In research models Tyrphostin 9 has been utilized to study receptor-mediated signal transduction and vascular injury-related neointimal proliferation processes